Salycilic acid has an important comedolytic, astringent and antimicrobial effect. When applied in high concentration it produces a frost or white epidermolysis on comedones and acneiform eruptions that allows the acid to penetrate from the follicular epithelium to the sebaceous gland. It is used with great effectiveness in acne, oily skin and seborrhea. Acne blemishes can be safely removed as it prevents bacterial spread by manipulating them.

Mandelic acid has a bigger molecular structure than other AHAs so it penetrates more slowly into the stratum corneum and requires a longer exposure time. For this reason it does not cause irritation or pruritus on the skin. Further it increases collagen, elastin and glycosaminoglycans synthesis in the papillary dermis. It also posseses an antimicrobial action.